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, 2008). In practical selectivity, one or more pathways are activated preferentially around others, generally as a result of ligand biasing and/or allosteric modulation (Goupil et al., 2012). It can be plausible the phytocannabinoid/terpenoid “entourage†that accompanies Δ9 -THC when marijuana is smoked may perhaps modulate Δnine -THC signaling in this manner. Practical selectivity diversifies the net effects that are probable from activating only only one receptor subtype and as a consequence may well support to clarify the variations noticed clinically involving marijuana use and K2 use.
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